Nitric oxide synthase immunity in the malaria non-vector Anopheles culicifacies species B: a putative transmission blocking Plasmodium vivax immune responsive mechanism for refractoriness

摘要

Background: Innate immune-related anti-parasite defenses mounted by Anopheles may suppress the growth of Plasmodium in mosquitoes. Nitric oxide (NO) produced by the action of an inducible NO synthase (NOS) and its gene elements kill malaria parasite in vitro and may be central to the anti-parasitic arsenal of this mosquito.