Mutation in Alkylhydroperoxidase D Gene Dramatically Decreases Persistence of Mycobacterium bovis Bacillus Calmette-Guerin in Infected Macrophage

摘要

Background:Mycobacterium tuberculosis is the leading cause of death from a single bacterial species in the world and in its host macrophage is subjected to a highly oxidative environment and consequently has evolved protection mechanisms against reactive oxygen and nitrogen intermediates. Alkyl hydroperoxidase D (AhpD) is a molecule from these mycobacterial defense systems that has a dual function. It not only works with Alkyl hydroperoxidase C (AhpC) in mycobacterial defense system against Oxidative stress but also has a role in oxidation/reduction of succinyltransferase B (SucB), dihydrolipoamide dehydrogenase(LPD) and AhpC.