Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. Robert A. Copeland. Hoboken, NJ: John Wiley & Sons, Inc., 2005, 271 pp., $84.95, hardcover. ISBN 0-471-68696-4. (Book web site http://www.chipsbooks.com/evalenz.htm)

摘要

Many drugs produce their pharmacologic effects by inhibiting enzymes, and the importance of this class of therapeutic agents has increased with the mapping of the human genome, which facilitates identification of novel enzyme targets. To produce a successful drug, however, it is essential that selective inhibitors be identified, which requires that each candidate be evaluated for potency against a plethora of potential targets. This analysis has fallen on the shoulders of the experts in enzyme kinetics in the pharmaceutical industry. With the increase in drug-related research in academia and with …