Bioinformatics for Geneticists. Michael R. Barnes and Ian C. Gray, editors. Chichester, West Sussex, United Kingdom: John Wiley & Sons Ltd., 2003, 422 pp., $65.00, softcover. ISBN 0-470-84394-2.

摘要

This book addresses a curious need for greater interaction between genetics and bioinformatics. One would expect the two disciplines to interact profusely, given, as the authors put it, their “strong common grounding in statistical methodology, dependence on efficient computational algorithms, rapidly growing biological data, and shared principles of molecular biology”. However, until recently, most of the research in bioinformatics has focused on sequencing genomes. That research goal, in particular, is quite “foreign to the core genetics principles of variability and individual differences” because it aims at discovering representative (consensus) sequences in a given species’ genome.Clearly, however, both disciplines can profit from, and indeed need, a deeper integration. The book aims, and succeeds, …