Methylation of the calcium channel regulatory subunit |[alpha]|2|[delta]|-3 (CACNA2D3) predicts site-specific relapse in oestrogen receptor-positive primary breast carcinomas

摘要

Background:Calcium is an important intracellular messenger that mediates many biological processes that are relevant to the malignant process. Calcium ion channels are key in controlling the intracellular calcium, and little is known about their role in human cancer.