B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma|[sol]|polyp (SSA|[sol]|P) and cancer in SSA|[sol]|P

摘要

Background:Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation analysis in aberrant crypt foci (ACF), SSA/P, and cancer in SSA/P specimens to show a close association between ACF and the SSA/P-cancer sequence. We also evaluated the prevalence and number of ACF in SSA/P patients.