Epstein-Barr Virus latent membrane protein 1 induces Snail and epithelial|[ndash]|mesenchymal transition in metastatic nasopharyngeal carcinoma

摘要

Background:Epstein-Barr Virus (EBV)-associated nasopharyngeal carcinoma (NPC) is distinctive among head-and-neck cancers in its undifferentiated histopathology and highly metastatic character. We have recently investigated the involvement of epithelial–mesenchymal transition (EMT) in NPC. In a previous study, we found a close association of expression of LMP1, the principal EBV oncoprotein, with expression of Twist and induction of EMT.