Regioselectivities in Fe(III)‐catalyzed Cycloisomerization Reactions of γ‐Allenyl Alcohols

摘要

Irona??catalyzed intramolecular hydroalkoxylation reactions of allenes were performed to provide various tetrahydrofurans by regioselective 5a??exo cyclization pathway, as the Lewis acidic activation of Fe(III) salts toward unsaturated C?￡?C bonds, allenes and alkenes. Cyclohexyl substituted allenes especially isomerized to dienes at a rapid rate, which underwent a competing 6a??endo cyclization mode. The plausible mechanism was presented by experimental results of the reaction intermediates and computational study of Fea??allene and Fea??diene complexes.