Fast, Efficient and Regioselective Conversion of Epoxides to β-Hydroxy Thiocyanates with NH₄SCN/Zeolite Molecular Sieve 4 Å under Solvent-Free Conditions

摘要

Solvent-free conversion of various epoxides to their corresponding β-hydroxy thiocyanates was carried out successfully with NH4SCN/zeolite molecular sieve 4 Å system at room temperature. The reactions were completed within 2 - 7 min to give thiocyanohydrins with perfect regioselectivity and isolated yields. Moreover, the zeolite can be reused for several times without losing its activity.