Synthesis, Molecular and Microstructural Study of Poly-N-Vinylpyrrolidone
Oximo-L-Valyl-Siliconate with IR, ¹H-NMR and SEM

摘要

By reducing PVP with H₂NOH.HCl and NaOH 2:2:1 mass ratios in aqueous ethanol, poly-N-vinyl pyrrolidone oxime [PVPO] was prepared with 92% yield. Applying the sol-gel concept, orthosilicic acid [OSA] was made by hydrolyzing TEOS with ethanol in 1:0.5 molar ratios using 1 N KOH aqueous solution as a catalyst. The OSA + PVPO + L-Valine (メ-amino acid) were mixed with pure ethanolic medium in 1:2:2 mass ratios and refluxed at 78 ^oC and 6 pH for 6.5 h. A white residue of poly-N-vinyl pyrrolidone oximo-L-valyl-siliconate [POVS] appeared after 5 h. The heating of reaction mixture was stopped and the contents were brought to NTP. The residue formation of POVS was intensified with lowering a temperature and completely solidified within 5 h, was filtered using a vacuum pump with Whatmann filter paper no. 42. The residue of POVS was washed several times with 20% aqueous cold ethanolic solution and dried in vacuum chamber at 25 ^oC for 24 h. The MP was noted above 350 ^oC. Structural and internal morphology were analyzed with IR and ¹H-NMR, and SEM respectively. A drug loading and transporting ability of the POVS in water and at pH = 5 and 8 was determined chromatographically.