Synthesis of 1,4-Dideoxy-1,4-imino-D-arabinitol (D-AB1) Through a Divergent Approach

Kyo Han Ahn; Yoo-Seung Shin

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Synthesis of 1,4-Dideoxy-1,4-imino-D-arabinitol (D-AB1) Through a Divergent Approach

机译：通过发散法合成1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇（D-AB1）

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摘要

A divergent approach to 2-(hydroxymethyl)pyrrolidine-3,4-diols has been studied with 1,4-dideoxy-1,4-imino-D-arabinitol (D-AB1), a potent glycosidase inhibitor. D-AB1 was efficiently synthesized from 2,3-epoxyalcohol 6a in overall 11% yield.

机译：已经用有效的糖苷酶抑制剂1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇（D-AB1）研究了2-（羟甲基）吡咯烷-3,4-二醇的不同方法。 D-AB1是由2,3-环氧醇6a有效合成的，总产率为11％。

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《Bulletin of the Korean Chemical Society》 |1997年第11期|共页
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Kyo Han Ahn; Yoo-Seung Shin;
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中图分类化学;
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机译：N-烷基化的1,4-二甲氧基-1,4-亚氨基-d-阿拉伯糖醇和1,4-二甲氧基-1,4-亚氨基-1-木糖醇的通用方法
2. Chirospecific synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol and 1,4-dideoxy-1,4-imino-L-xylitol via one-pot cyclisation [J] . Kim JH., Lee WS., Park KH., Journal of the Chemical Society, Perkin Transactions 1 . 1998,第17期

机译：通过一锅环化反应进行1,4-二脱氧-1,4-亚氨基-D-阿拉伯糖醇和1,4-二脱氧-1,4-亚氨基-L-木糖醇的手性合成
3. A flexible and efficient synthesis of the pyrrolidine alpha-glycosidase inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol (DAB-1) [J] . Hulme AN., Henderson DK., Montgomery CH. Journal of the Chemical Society, Perkin Transactions 1 . 2000,第12期

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Synthesis of 1,4-Dideoxy-1,4-imino-D-arabinitol (D-AB1) Through a Divergent Approach

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