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Pragmatic randomised trial of a 12-week exercise and nutrition program for Aboriginal and Torres Strait Islander women: clinical results immediate post and 3?months follow-up

机译:一项针对原住民和托雷斯海峡岛民妇女的为期12周的运动和营养计划的实用随机试验:临床结果立即发布,随访3个月

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Background Aboriginal and Torres Strait Islander women experience higher rates of heart disease and type 2 diabetes than non-Indigenous Australian women. Increasing physical activity, improving diets and losing weight have been shown to reduce cardio metabolic risk. The primary aim was to evaluate the effectiveness of a 12-week structured exercise and nutrition program in a cohort of urban Indigenous Australian women on waist circumference, weight and biomedical markers of metabolic functioning from baseline (T1) to program completion (T2). The secondary aim assessed whether these outcomes were maintained at 3-month follow-up. Methods One hundred Aboriginal and/or Torres Strait Islander women aged 18–64?years living in the Adelaide metropolitan area were recruited. The program included two 60-minute group cardiovascular and resistance training classes per week, and four nutrition education workshops. Participants were randomly assigned to an ‘active’ group or ‘waitlisted’ control group. Body weight, height, waist and hip circumference, blood pressure, fasting glucose, fasting insulin, glycated haemoglobin (HbA1C), lipid profile and C-reactive protein (CRP) were assessed at baseline (T1), immediately after the program (T2) and three months post program (T3). Results The active group showed modest reductions in weight and body mass index (BMI). Compared to the waitlisted group, the active group had a statistically significantly change in weight and BMI from baseline assessments; at T2, -1.65?kg and -0.66?kg/m2 and at T3, -2.50?kg and -1.03?kg/m2, respectively. Systolic and diastolic blood pressure also had a statistically significant difference from baseline in the active group compared to the waitlisted group at T2, -1.24?mmHg and -2.46?mmHg and at T3, -4.09?mmHg and -2.17?mmHg, respectively. The findings were independent of the baseline measure of the outcome variable, age, households with children and employment status. Changes in waist circumference and other clinical measures were not significant at T2 or T3. The primary outcome measure, waist circumference, proved problematic to assess reliably. Missing data and participants lost to follow-up were significant. Conclusions This 12-week exercise program demonstrated modest reductions in weight, BMI and blood pressure at T2, which improved further at 3-month follow-up (T3). Positive intervention effects were observed despite low attendance at exercise classes. Structured exercise programs implemented in community settings require attention to understanding the barriers to participation for this high risk group. Trial registration Australian New Zealand Clinical Trials Registry ACTRN12610000224022
机译:背景土著居民和托雷斯海峡岛民妇女比非土著澳大利亚妇女患心脏病和2型糖尿病的几率更高。研究表明,增加体育锻炼,改善饮食和减轻体重可以降低心脏代谢风险。主要目的是评估一组为期12周的结构化运动和营养计划在一组澳大利亚城市土著妇女的腰围,体重和从基线(T1)到计划完成(T2)的代谢功能的生物医学指标方面的有效性。次要目标是评估这些结果是否在3个月的随访中得以维持。方法招募一百名居住在阿德莱德市区的18-64岁的原住民和/或托雷斯海峡岛民妇女。该计划包括每周两次60分钟的小组心血管和抵抗力培训班,以及四个营养教育讲习班。参与者被随机分配到“活动”组或“等待名单”的对照组。程序结束后立即在基线(T1)评估体重,身高,腰围和臀围,血压,空腹血糖,空腹胰岛素,糖化血红蛋白(HbA1C),脂质分布和C反应蛋白(CRP)计划发布后三个月(T3)。结果活动组的体重和体重指数(BMI)有所降低。与等待组相比,活动组的体重和BMI较基线评估有统计学上的显着变化。在T2,- 1.65?kg和- 0.66?kg / m 2 ,在T3,- 2.50? kg和- 1.03?kg / m 2 。在T2,- 1.24?mmHg和- 2.46?mmHg时,活动组的收缩压和舒张压与等待组相比,也有统计学差异。 T3分别为- 4.09?mmHg和- 2.17?mmHg。这些发现与结果变量,年龄,有孩子的家庭和就业状况的基线测量值无关。在T2或T3时腰围和其他临床指标的变化不明显。主要结果指标腰围证明难以评估。数据丢失和参与者失去随访的意义重大。结论这项为期12周的运动计划表明,在T2时体重,BMI和血压均有适度的降低,在3个月的随访(T3)中进一步改善。尽管参加健身课程的人数很少,但仍观察到积极的干预效果。在社区环境中实施的结构化锻炼计划需要注意了解这一高风险人群参与的障碍。试验注册澳大利亚新西兰临床试验注册中心ACTRN12610000224022

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