Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types

David A Sallman; David E Gilham; Philippe Aftimos; Jason B Brayer; Tessa Kerre; Eric Van Den Neste; Fanny Piette; Gaetan Catala; Alain Hendlisz; Jean-Pascal H Machiels; Bikash Verma; Marco L Davila; Caroline Lonez; Ahmad Awada; Frédéric F Lehmann; Kunle Odunsi

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Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types

机译：THINK的研究方案：一项跨国的开放标签的第一阶段研究，旨在评估NKR-2多次给药对不同转移性肿瘤类型患者的安全性和临床活性

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Abstract Introduction NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3???? signalling domain, which associates with the adaptor mo

机译：摘要简介NKR-2是自体T细胞，经过基因修饰以表达嵌合抗原受体（CAR），该嵌合抗原受体包括2D自然杀伤基团（NKG2D）受体与CD3β3融合体。与适配器模块关联的信令域

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《BMJ Open》 |2017年第11期|共页
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David A Sallman; David E Gilham; Philippe Aftimos; Jason B Brayer; Tessa Kerre; Eric Van Den Neste; Fanny Piette; Gaetan Catala; Alain Hendlisz; Jean-Pascal H Machiels; Bikash Verma; Marco L Davila; Caroline Lonez; Ahmad Awada; Frédéric F Lehmann; Kunle Odunsi;
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中图分类临床医学;
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Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types

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