A primary chondrosarcoma was found in the epiglottis of a 6-year-old, neutered, male Boxer cross-breed dog. Clinically, there was upper respiratory noise, and a 3.2 cm × 2.8 cm × 2.7 cm, ovoid mass involving the epiglottis was observed. No abnormalities were detected upon radiographic examinations (X-ray) of the chest or abdomen. Grossly, the excised mass was hard. On cut section, it displayed a lobular pattern of translucent gray-white color (interpreted as cartilage). Histologically, the epiglottal submucosa contained a non-encapsulated, fairly demarcated multi-nodular neoplasm composed of streams of cells admixed with moderate to abundant amounts of a pale amphophilic to eosinophilic matrix (chondroid). The neoplastic cells stained were immunohistochemically positive for vimentin and S-100 protein, and negative for pancytokeratin. The matrix stained deeply with Alcian Blue (pH 2.5)-periodic acid Schiff, which often separated cells into individual lacunae. To the best of our knowledge, this is the first report of extra-skeletal chondrosarcoma primarily arising in the epiglottis of a dog.
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