MR thermometry for focused ultrasound monitoring utilizing model predictive filtering and ultrasound beam modeling

摘要

Background A major challenge in using magnetic resonance temperature imaging (MRTI) to monitor focused ultrasound (FUS) applications is achieving high spatio-temporal resolution over a large field of view (FOV). This is important to accurately monitor all ultrasound (US) power depositions. Magnetic resonance (MR) subsampling in conjunction with thermal model-based reconstruction of the MRTI utilizing Pennes bioheat transfer equation (PBTE) is one promising approach. The thermal properties used in the thermal model are often estimated from a pre-treatment, low-power sonication. Methods In this proof-of-concept study we investigate the use of US simulations computed using the hybrid angular spectrum (HAS) method to estimate the US power deposition density Q , thereby avoiding the pre-treatment sonication and any potential tissue damage. MRTI reconstructions are performed using a thermal model-based reconstruction method called model predictive filtering (MPF). Experiments are performed in a homogeneous gelatin phantom and in a gelatin phantom with embedded plastic skull. MPF reconstructions are compared to separate sonications imaged with fully sampled data over a smaller FOV. Temperature root-mean-square errors (RMSE) and focal spot positions and shapes are evaluated. Results HAS simulations accurately predict the location of the focal spot (to within 1?mm) in both phantoms. Accurate temperature maps (RMSE below 1?°C), where the location of the focal spot agrees well with fully sampled “truth” (to within 1?mm), are also achieved in both phantoms. Conclusions HAS simulations can be used to accurately predict the focal spot location in homogeneous media and when focusing through an aberrating plastic skull. The HAS simulated power deposition ( Q ) patterns can be used in the MPF thermal model-based reconstruction to obtain accurate temperature maps with high spatio-temporal resolution over large FOVs.