Sequence analysis of the cDNA encoding for SpCTx: a lethal factor from scorpionfish venom (Emphasis Type="Italic"Scorpaena plumieri/Emphasis)

摘要

BackgroundLethal factors are multifunctional oligomeric proteins found in the venomous apparatus of Scorpaeniformes fish. These toxins elicit not only an array of biological responses in vitro but also cardiovascular disorders and strong hemolytic, nociceptive and edematogenic activities in vivo. This work describes the cloning and molecular identification of two toxin subunits, denominated Sp-CTx-?± and Sp-CTx-?2, from scorpionfish venom (Scorpaena plumieri).