Trends of CD4 count after inBengalitiation of antiretroviral therapy and the predictors of immunological non response in HIV infected patients in a tertiary care centre of Souther

摘要

This retrospective cross sectional study was done by reviewing the records of 422 patients of HIV (who received ART from the ART clinic of Midnapore Medical College) to assess the trends in CD4 cell recovery among HIV patients after initiation of ART, the effect of different baseline characteristics on CD4 cell count response & to find out predictors of immunological non response (Rise of CD4 counts of 350, 201-350 & 350 cells/μl. The patients with a lower baseline CD4 had lower peak CD4 counts. Patients with lower CD4 counts at the beginning had subsequent poor CD4 recovery & higher chances of immunological non response as well. Female patients & patients of WHO clinical stage 4 was also found to be at significantly higher risk of immunological non response. Our findings suggest that HAART should be initiated early for better immune recovery & female patients should be given more consideration regarding adherence to the therapy.