DOES PROBIOTIC AND PREBIOTIC TREATEMENT IN IVF CYCLES OF INFERTILE WOMEN WITH INTESTINAL DYSBIOSIS, AFFECT PREGNANCY RATE?

摘要

Background : Several findings show how as the intestinal microbiota regulates some important metabolic and physiological body functions, as production of toxic or useful substances, induction of inflammatory processes and interaction with immune system. Alterations of the intestinal microbiota can occur by changes in composition (dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases as bacterial vaginosis (BV). Objectives : the aim of this study is to understand if there is a correlation between acute intestinal dysbiosis condition and the failure in IVF freeze embryo transfer(FET)cycles, and if a prebiotic and probiotic treatment can improve the success rate. Search strategy: we investigate about the incidence of pregnancy rate in acute-severe dysbiotic patients and prebiotics–probiotics treated patients undergoing to a FET cycle. Selection criteria: 53 patient with acute or severe intestinal dysbiosis undergoing IVF cycle was recruited and randomized in two group. Group A (n=29) (control group) and Group B (n=24) have to transfer two freeze embryos each. Group B was treated with prebiotic and probiotic for at least two months to reduce the dysbiosis condition from acute-severe to mild-moderate level. Main results: After FET in the group A there have been 5 ongoing pregnancy and 3 born baby, in the group B (treated group) there was been 15 pregnancy(p<0,05) and 12 born baby (p<0,05) Conclusion : Our result show that a treatment whit probiotic and prebiotic is able to increase pregnancy rate in IVF cycles of infertile women affected by acute or severe intestinal dysbiosis, by modulation of some crucial mechanisms involved in embryo implantation.