A comparative study of preemptive effect of pregabalin and gabapentin on postoperative pain after coronary artery bypass graft surgery: A clinical randomized trial

摘要

BackgroundPain that pursues coronary artery bypass graft (CABG) surgery is usually associated with increased both recovery duration and hospital stay. Patient outcome could be worsened owing to large doses of opioids for pain control through over sedation, and prolonged mechanical ventilation. This study was designed to evaluate the effect of preemptive gabapentinoids on post CABG surgery pain control.MethodsSixty patients subjected to CABG were randomized blindly to receive either pregabalin, gabapentine or placebo 2?h before the surgery. The former group included 20 patients who received 150?mg pregabalin, whereas the later group included another 20 patients who received 600?mg gabapentin. Finally, the placebo group with number of 20 patients received identical capsule. The postoperative pain was assessed with critical care pain observation tool (CPOT) and Numeric rate score (NRS). Total administered of patient controlled analgesia (PCA) with morphine as well as any rescue doses were registered and patient satisfaction was recorded.ResultsOut of the 60 eligible patients, 56 patients were enrolled in the study (with male predominance 51: 5). Enrollment at gabapentin, pregabalin and placebo groups was (19, 18 and 19 respectively). Post-operative patient satisfaction was better in the pregabalin group with value 8.1?±?1.1 compared to 7.9?±?1 in the gabapentin group, and 6.7?±?1.2 in the placebo group (P?