Immunoregulation in Urinary Tract Inflammationa€”A Role of Tamm-Horsfall Glycoprotein Tamm-Horsfall Glycoprotein Links Innate Immune Cell Activation with Adaptive Immunity via a Toll-Like Receptor-4a€“Dependent Mechanism. J Clin Invest 115: 468a€“475, 2005

摘要

The Tamm-Horsfall protein (THP), the most abundant protein in normal urine, was discovered five decades ago (1), or possibly even much earlier (2), but the role for the most abundant protein in normal urine had remained enigmatic for a long time. It is expressed in the thick ascending limb of Henlea€?s loop and the early distal convoluted tubule (3). Meanwhile, the important role of mutations of its gene in the genesis of an autosomal dominant form of progressive chronic renal failure with hyperuricemia with or without medullary cysts has been clearly established (4), consistent with an important biologic function of this protein.