Synergistic role of prolactin and testosterone in the regulation of acid phosphatase activity and isoenzyme pattern in the accessory sex organs of adult male rats

摘要

Summary. Testosterone treatment of adult castrated rats maintains the activity and isoenzyme pattern of acid phosphatase in the ventral prostate and seminal vesicle glands. However, testosterone fails to have this effect in rats hypophysectomized and castrated or in castrated rats treated with bromocriptine. Concurrent treatment with prolactin restores the normal acid phosphatase pattern, suggesting that prolactin has a synergistic role with testosterone in the regulation of acid phosphatase activity and its isoenzyme pattern in male rat accessory sex organs.