Association study of angiotensin II type 1 receptor: A1166C (rs5186) polymorphism with coronary heart disease using systematic meta-analysis

摘要

Angiotensin II type 1 receptor (AT1R) mediates the cardiovascular actions of angiotensin II. Growing studies have revealed the underlying association between AT1R-A1166C (rs5186) polymorphism and coronary heart disease (CHD) among the East Asia population. Results from these studies remain conflicting. We conducted this meta-analysis to estimate the overall CHD risk of AT1R-A1166C polymorphism regarding the East Asia population. We searched the PubMed, Embase and China National Knowledge Infrastructure (CNKI) databases for all articles within a range of published years from 1995 to 2011. The odds ratio (OR) corresponding to the 95% confidence interval (CI) was used to assess the different associations. The statistical heterogeneity among studies was assessed with the Q-test and I 2 statistics. Up to December 2011, 17 case-control studies, including 2,366 cases and 2,414 controls, were available for our study. The C allele and the AC/CC genotypes were associated with significantly increased risk of CHD (OR = 1.59, 95% CI = 1.22–2.06 for C versus A and OR = 1.57, 95% CI = 1.16–2.13 for AC/CC versus AA, respectively). Our result suggested that AT1R-A1166C polymorphism may be involved in the development of CHD.