Old Age and Aerobic Microorganisms of Patients Affected by M.????Clostridium difficile Infection are Associated Primarily with the Intestinal Presence of Clostridium difficile

摘要

Clostridium difficile infection in human occurs when the organism is present and germinating in the bowel. Old age of patients’ and particular microorganisms in stools are identified as risk factors for the disease onset. We aimed to investigate if risk factors for C. difficile infections in a large Italian hospital were connected to C. difficile intestinal presence or to germination. Toxin B positivity was linked with age over 65 years (P=0.03), medical hospitalization (P=0.015) and growth of Enterobacteriaceae (P=0.029) and Enterococcus (P=0.05) from the same stools. The presence of tcdB was even more strictly linked with old age (P=0.005), medicine hospitalization (P=0.012) and growth of Enterobacteriaceae (P=0.003) and Enterococcus (P=0.04). Our results indicated that the presence of C. difficile in stools, irrespective of being spore or vegetative form, is reliably associated with old age of subjects and fecal presence of viable Enterobacteriaceae and Enterococcus.