Platelet rich plasma from umbilical cord blood with Chinese medicine formula Ling Zhi and San-Miao-San in hyaluronic gel for articular cartilage retrieval in rat osteoarthritis model

摘要

Osteoarthritis (OA) is the most common degenerative joint dis- ease. Umbilical cord blood (UCB) Platelet Rich Plasma (PRP) is an autologous, non-immunogenic concentrate of platelets and a rich source of growth factors. Hyaluronic acid (HA) gel scaffolds function as a delivery vehicle, which augment platelet viability in UCB PRP with the traditional Chinese medicine formulas Ling zhi (LZ) and San-Miao-San (SMS). Our aim is to address this issue and UCB PRP therapy, specifically using the potential therapeutic activities of LZ-SMS, which has been used empirically for the treatment of OA, to promote chondrocyte pro- liferation and exhibit additive or synergistic immunoregulatory effects for the articular cartilage retrieval at a rodent model of traumatic OA and subsequent cartilage damage. Subjects and.