Retinal vasculitis associated with pyoderma gangrenosum: a case report

摘要

Introduction Pyoderma gangrenosum (PG) is an uncommon, idiopathic ulcerative neutrophilic inflammatory skin disease characterized by variable clinical presentation, and the cause of this disease is uncertain [1]. Diagnosis of pyoderma gangrenosum is clinical, and histopathology is not specific and depends on exclusion of other causes of cutaneous ulceration [2]. Clinically it starts with sterile pustules that rapidly progress and become painful ulcers of different size with violaceous borders. The legs are most commonly affected, but other parts of the skin and mucous membranes may also be involved [3]. PG commonly occurs between 25 and 54 years of age and occurs rarely in children. The estimated incidence of PG is approximately 3–10 patients per 1,000,000 population per year [4]. Approximately 50 % of patients have an associated systemic disease, commonly inflammatory bowel disease (IBD), ulcerative colitis, arthritis, hematological and lymphoreticular malignancies, while in another 40–50 % patients, no underlying disease is found. The disease is recurrent in approximately 30 % of patients [5, 6]. The management of PG is treatment of underlying systemic medical illness and judicious use of immunosuppressants.