Maternal Serum Aneuploidy Screen and Adverse Pregnancy Outcomes

摘要

Objective To find out whether maternal serum screening for fetal chromosomal aneuploidy predicts adverse pregnancy outcomes. Methods A two-year retrospective case–control study was conducted at a tertiary hospital. Pregnant women with a high-risk serum screen but with chromosomally normal fetuses ( n =?189) were compared to those with low-risk screen (controls, n =?157) for adverse pregnancy outcomes. Results Women with high-risk double marker or combined screen were found to have higher prevalence of LBW [OR 2.56; 95?% CI (1.01–6.53), p p p p p R 2?=?12.2?%, β ±?SE?=?0.224?±?0.069; p R 2?=?4.9?%, β ±?SE?=?0.613?±?0.296; p R 2?=?9.2?%, β ±?SE?=??0.077?±?0.025; p p p Conclusion A “high-risk” maternal serum screen with abnormal PAPP-A and/or beta hCG/HCG is associated with adverse pregnancy outcomes and may help identifying women requiring additional fetal surveillance.