An Epidemiological Study of Confirmed H1N1 Admitted Cases in an Infectious Disease Hospital, Pune

摘要

Background: Pune was at the epicenter of In-fluenza A (H1N1) epidemic that struck thecountry during the middle of 2009. Initially allthe persons with a positive PCR test for H1N1were customarily admitted to the infectiousdisease hospital; but later on the facility foradmission of severe category of patients wasmade available at two other hospitals in Punecity. Objectives: To know the epidemiologicalfeatures of Influenza A (H1N1) during the ini-tial stages of the epidemic. Method and Mate-rials: All the patients admitted to the infectiousdisease hospital during June-October 2009 witha confirmed Influenza A (H1N1) PCR test wereconsidered for the study. Statistical analysis:Mean, SD, Inter-quartile Range, Chi-square.Results: Less than 30 years comprised 87.6percent and students were in majority (63.38%) out of the total 284 patients studied. Themean duration of illness for H1N1 was 6.8 days(inter-quartile range of 5-8 days). The clinicalpicture was almost similar in both male and fe-male patients. Co-morbid conditions were ob-served in 15.8 percent patients. The complica-tion rate in patients with respiratory co-mor-bid conditions was significantly higher. Initially,the proportion of patients with history of for-eign travel was high; later on their proportiondecreased to a very low level while an increasein the proportion of patients with history ofcontact with a known H1N1 patient was ob-served as the epidemic progressed. Nearly halfof the families had not taken Oseltamivirchemoprophylaxis while 35.6 percent patientswere administered Oseltamivir within 48 hrs ofstarting of symptoms. There was no mortalityin the patients studied. Conclusions: A studyof 284 confirmed cases of Influenza A (H1N1)in Pune city showed epidemiological featuresof the disease such as age, gender, history ofcontact, foreign travel, co-morbidity and com-plication rate and the oseltamivir prophylaxis.