Changes of immune function and serum levels of inflammatory cytokines in patients with primary biliary cirrhosis

摘要

Objective: To explore the changes of immune function and serum inflammatory cytokines levels in patients with primary biliary cirrhosis. Methods: Fifty-five patients with primary biliary cirrhosis who were treated in our hospital from June 2015 to January 2017 were selected as the observation group and 55 healthy subjects were selected as the control group. The liver function, immune function and inflammatory cytokines levels were measured. Results: The levels of ALT, AST and TBIL in observation group were (103.2±6.14) U/L, (96.07±3.48) U/L and (86.60±8.25) 毺mol/L respectively, which were significantly higher than those in control group, the difference was statistically significant; The levels of IL-6, IL-8, IL-10 and TNF-α in the observation group were (68.47±10.70) pg/mL, (881.49±94.50) pg/mL, (50.49±5.22) pg/mL and (429.45±96.13) pg/mL, which were significantly higher than those in healthy controls; The percentage of CD3 + , CD4 + , CD8 + and CD4 + /CD8 + in the observation group were (68.73±7.21)%, (42.31±1.06)%, (20.27±1.1)% and (2.35±0.08)%, and the CD3 + , CD4 + , CD4 + / CD8 + levels were obviously higher than control group. There was no significant difference in CD8 + level compared with control group. Conclusion: Patients with primary biliary cirrhosis have abnormal liver function, immune dysfunction and inflammatory response, which should be timely monitored in clinical treatment so as to treat the disease more effectively.