Changes of immune response and side effects before and after nutritional intervention in cervical cancer patients with concurrent chemoradiotherapy

摘要

Objective: To investigate the changes of immune response and side effects before and after nutritional intervention in cervical cancer patients with concurrent chemoradiotherapy. Methods: A total of 160 patients with primary cervical cancer who received concurrent chemoradiotherapy in this hospital between May 2016 and September 2017 were selected as the research subjects. Their nutritional intervention plans were reviewed and used to divide the patients into the control group (n=83) who accepted conventional nutritional support and the nutritional intervention group (n=77) who accepted targeted nutritional intervention. The differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were compared between the two groups before and after intervention. Results: Before intervention, the differences in the contents of Th1/Th2 immunity indexes and humoral immunity indexes as well as the levels of bone marrow suppression-related indexes were not statistically significant between the two groups. After intervention, serum IL-2, IFN-γ, IL-4 and IL-6 contents of nutritional intervention group were lower than those of control group; serum IgA, IgM, IgG, C3 and C4 contents were higher than those of control group; peripheral blood WBC, RBC, Hb and PLT levels were higher than those of control group. Conclusion: Nutritional intervention can effectively optimize the immune status and reduce the bone marrow suppression reaction in cervical cancer patients with concurrent chemoradiotherapy.