Effects of lentinan and thymopentin combined with adjuvant chemotherapy on immunity, oxidative stress, matrix metalloproteinases and related factors in patients with tongue squamous cell carcinoma

摘要

Objective: To investigate the effects of lentinan and thymopentin combined with adjuvant chemotherapy on immunity, oxidative stress, matrix metalloproteinases and related factors in patients with tongue squamous cell carcinoma. Methods: Retrospective analysis of 78 patients with tongue squamous cell carcinoma admitted to our hospital from February 2013 to November 2017, according to the postoperative chemotherapy scheme, the patients were divided into control group (n=42) and observation group (n=36). The patients in control group were given PF chemotherapy scheme (cisplatin + compound fluorouracil injection), on this basis, the patients in observation group were given lentinan and thymopentin injection combined treatment. The immune index, oxidative stress, matrix metalloproteinase, cyclin D1 (CyclinD1) and B lymphocyte tumor-2 (BCL-2) were detected and analyzed before and after treatment. Results: After treatment, the immunoglobulin level in the control group was not statistically significant compared with that before treatment (P0.05); the levels of IgA, IgG and IgM in the observation group were significantly higher than those before treatment (P 0.05), and the levels of IgA, IgG and IgM in the observation group were significantly higher than those in the control group (P0.05); the level of SOD in control group was significantly lower than that before treatment (P0.05), and the level of MDA was significantly higher than that before treatment (P0.05); the observation group was the opposite, and its SOD level was significantly higher than that of the control group (P0.05), and the MDA level was significantly lower than the control group (P0.05); the levels of MMP-2 and MMP-9 in the two groups were significantly lower than those before treatment (P0.05), and the levels of MMP-2 and MMP-9 in the observation group were significantly lower than those in the control group (P0.05); the levels of CyclinD1 and BCL-2 in the two groups were significantly lower than those before treatment (P0.05), and the levels of CyclinD1 and BCL-2 in the observation group were significantly lower than those in the control group (P0.05). Conclusions: Lentinan and thymopentin assisted PF chemotherapy regimen can enhance the immune function of patients with tongue squamous cell carcinoma after radical surgery, improve oxidative stress response, inhibit tumor cell proliferation and metastasis. It has the significance of clinical popularization.