A clinical, hematological, biochemical and radiological assessment of dental fluorosis in endemic fluoridated area of Maharashtra, India

摘要

Aim: There is worldwide evidence that fluoride intake above tolerance levels over certain period leads to cumulative effect resulting in systemic illness and osteosclerosis. The study was conducted where the drinking water content of fluoride was 4.7 ppm to evaluate the effect of fluorosis. Materials and methods: Study was conducted in Maharashtra, India. An ethical clearance was obtained. Clinical, biochemical, hematological and radiological assessment of all the patients were done. Results: Clinical grading of dental fluorosis in male (M) and female (F) patients was 1.85 ? 0.84 and 1.91 ? 0.86. RBC count in M/F was 4_93 ? 0 49 and 4.50 ? 0.47 (p-value 0.003). Hb% in MIF was 12.14 ? 1.76 and 11.21 ? 1.34 (p-value 0.038). Alkaline phosphate level in M/F was 279.68 ? 152.09 and 271.68 ? 169.97. ESR count in MIF was 10 41 ? 8.75 and 1229 ? 7.37. Radiological finding shows, enlarge pulp chamber 31.37%, prominent marrow 52.94%, thickening of inner and outer tables 83.92%, and harrowing of long bone 7.84%. Conclusion: Early diagnosis and identification of endemic area for fluorosis helps to prevent the further dental and skeletal changes. There is direct association between high concentration of fluoride in drinking water and involvement of dental structures.