Effects of preoperative intra-arterial interventional chemotherapy on cancer cell proliferation and invasion in advanced gastric cancer

摘要

Objective: To study the effect of preoperative intra-arterial interventional chemotherapy oncancer cell proliferation and invasion in advanced gastric cancer. Methods: A total of 134patients with advanced gastric cancer who received preoperative intra-arterial interventionalchemotherapy in AVIC 363 Hospital between May 2014 and September 2016 were selected,and 5-fluorouracil + oxaliplatin + mitomycin solution was used for preoperative intra-arterialinterventional chemotherapy. Before and after chemotherapy, gastric cancer lesions werecollected respectively, and enzyme linked immunosorbent assay kits were used to detect theexpression of pro-proliferation genes C-met, CypA, GOLPH3 and PTP1B, tumor suppressorgenes EAF2, ELL, ING5, GKN1 and GKN2 as well as invasion-related genes MMP2,MMP7, MMP11, Snail and Twist. Results: After interventional chemotherapy, C-met, CypA,GOLPH3, PTP1B, MMP2, MMP7, MMP11, Snail and Twist protein expression in gastriccancer lesions were significantly lower than those before interventional chemotherapy whileEAF2, ELL, ING5, GKN1 and GKN2 protein expression were significantly higher than thosebefore interventional chemotherapy. Conclusion: Preoperative intra-arterial interventionalchemotherapy has a significant inhibitory effect on the proliferation and invasion of cancercells in advanced gastric cancer.