Effects of naloxone hydrochloride on pulmonary function, blood gas changes and inflammatory factors in patients with COPD combined with respiratory failure

摘要

Objective: To investigate the effects of naloxone hydrochloride on pulmonary function, bloodgas changes and inflammatory factors in patients with COPD combined with respiratoryfailure. Methods: According to random data table method, 80 cases of COPD combined withrespiratory failure were randomly divided into the control group (n=40) and observation group(n=40), patients in the control group were treated with noninvasive positive pressure ventilationon the basis of routine symptomatic treatment, on the basis of the treatment of the controlgroup, the observation group received naloxone hydrochloride therapy. The levels of pulmonaryfunction, blood gas changes and inflammatory factors were compared in two groups beforeand after treatment. Results: The levels of serum FEV1, FVC, PEF, PaCO2, PaO2, PaO2/FiO2,TNF-毩 and PCT in the two groups before treatment were not statistically significant. Aftertreatment, the levels of FEV1, FVC, PEF in the control group and observation group were(70.01±0.36)%, (2.16±0.41) L, (2.98±0.45) L/s and (81.71±0.53)%, (3.65±0.55) L, (4.36±0.43)L/s, which were significantly higher than those in the same group before treatment, and thelevels in observation group were significantly higher than those in the control group; the levelsof PaCO2, PaO2 and PaO22/FiO2 in the two groups were (59.62±6.47) mmHg, (65.53±7.36)mmHg, (323.89±10.47) and (46.59±6.64) mmHg, (73.65±8.26) mmHg, (398.64±14.06),compared with the same group before treatment, PaCO2 levels were significantly lowerin both groups, and the observation group was significantly lower than the control group,PaO2,PaO2/FiO2 levels were significantly increased in both groups, and the observation groupwas significantly higher than the control group; the levels of TNF-α, PCT in the two groupswere (23.28±4.53) pg/mL, (5.22±2.13) ng/mL and (16.61±4.12) pg/mL, (2.07±1.21) ng/mL,which were significantly lower than those in the same group before treatment, moreover, theobservation group levels were significantly lower than those in the control group. Conclusion:Treatment of COPD with respiratory failure by naloxone hydrochloride can effectively reducethe level of inflammatory factors, and improved lung function and blood gas levels, which hasimportant clinical value.