Effect of hydromorphone hydrochloride combined with ropivacaine for PCEA after transurethral resection of prostate on pain mediators and stress response

摘要

Objective: To study the effect of hydromorphone hydrochloride combined with ropivacaine forpatient-controlled epidural analgesia (PCEA) after transurethral resection of prostate on painmediators and stress response. Methods: A total of 138 patients who received transurethralresection of prostate in Ankang Central Hospital between May 2014 and October 2016 wereselected and randomly divided into group A and group B, group A received postoperativehydromorphone hydrochloride combined with ropivacaine for PCEA, and group B receivedpostoperative morphine hydrochloride combined with ropivacaine for PCEA. The serumcontents of pain mediators, inflammatory response cytokines and stress hormones of the twogroups were detected before surgery as well as 12 h, 24 h and 48 h after surgery. Results: 12h, 24 h and 48 h after surgery, serum SP, BK, HIS, CX3CL1, CCL2, IL-1β, TNF-α, IL-10,ACTH, CORT, TSH, FT3, FT4 and GH levels of both groups of patients were significantlyhigher than those before surgery, and serum SP, BK, HIS, CX3CL1, CCL2, IL-1β, TNF-α,IL-10, ACTH, CORT, TSH, FT3, FT4 and GH levels of group A were significantly lower thanthose of group B. Conclusion: Hydromorphone hydrochloride combined with ropivacaine forPCEA can effectively reduce the pain and stress after transurethral resection of prostate.