Mechanism of edaravone combined with urinary kallidinogenase for acute cerebral infarction patients

摘要

Objective: To study the effects of Atorvastatin calcium combined with Aspirin on serum levelsof homocysteine (Hcy), neuron-specific enolase (NSE), uric acid (UA), high sensitity C-reactiveprotein (hs-CRP) and inflammatory factors of patients with cerebral infarction. Methods: 100cases of patients with cerebral infarction from March 2014 to May 2016 were treated in theDepartment of Neurology of our hospital and affiliated to Huazhong University of Science andTechnology of traditional Chinese medicine and Western Medicine. The subjects were dividedinto the control group (n=50) and the treatment group (n=50) randomly. The control group wastreated with Aspirin, the treatment group were treated with Atorvastatin calcium combinedwith Aspirin. The two groups were treated for 28 d. The serum levels of Hcy, NSE, UA, hs-CRP, interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) of thetwo groups before and after treatment were compared. Results: There were no significantlydifferences of the serum levels of the Hcy, NSE, UA and hs-CRP of the two groups beforetreatment (P0.05). After treatment, the serum levels of the Hcy, NSE, UA and hs-CRPof the two groups were significantly lower than before treatment, and that of the treatmentgroup were significantly lower than the control group (P0.05). After treatment, the serum levels of the IL-6, IL-8 and TNF-α of the two groups weresignificantly lower than before treatment, and that of the treatment group were significantlylower than the control group (P0.05). Conclusions: Atorvastatin calcium combined withAspirin can significantly reduce the serum levels of Hcy, NSE, UA, hs-CRP, IL-6, IL-8 andTNF-α of the patients with cerebral infarction.