Effects of preoperative concurrent radiochemotherapy on the cancer cell infiltration and angiogenesis in local advanced gastric cancer lesions

摘要

Objective: To study the effects of preoperative concurrent radiochemotherapy on the cancercell infiltration and angiogenesis in local advanced gastric cancer lesions. Methods: A total of68 patients who were diagnosed with locally advanced gastric cancer in this hospital betweenFebruary 2015 and April 2017 were selected as the research subjects and randomly dividedinto two groups, the radiochemotherapy group received capecitabine + cisplatin chemotherapycombined with intensity modulated radiation therapy before operation, and chemotherapygroup received preoperative capecitabine + cisplatin chemotherapy. The gastric cancer lesionssurgically removed from two groups of patients were collected to determine the expression ofproliferation-related genes, invasion-related genes and angiogenesis-related genes. Results:Rab27B, Bax, Caspase-3, PTPN13, E-cadherin and THBS2 protein expression in gastriccancer lesions of radiochemotherapy group were greatly higher than those of chemotherapygroup whereas EZH2, PRR1, EPHA2, HDAC5, N-cadherin, Twist1, ANGPTL2, ANGPTL5,GOLPH3 and HIF-1α protein expression were greatly lower than those of chemotherapy group.Conclusion: Preoperative concurrent radiochemotherapy has inhibitory effect on the cancercell infiltration and angiogenesis in local advanced gastric cancer lesions.