Analysis of the effect of Chlamydia pneumoniae on the lipid metabolism of mononuclear macrophages in patients with carotid atherosclerotic plaque

摘要

Objective: To explore the effect of Chlamydia pneumoniae on the lipid metabolism ofmononuclear macrophages in patients with carotid atherosclerotic plaque. Methods: A totalof 90 patients with carotid atherosclerosis who were admitted in our hospital from January,2012 to December, 2013 were included in the study and served as the observation group, while72 aged individuals at the same stage for physical examination were served as the controlgroup. The plaque formation in the two groups was observed and compared. The levels ofTC, LDL-C, and HDL-C in the two groups were detected and compared. ELISA was used todetect CP IgG. The positive rate of CP IgG in the two groups was compared. Results: Themultiple plaque, soft plaque, and mixed plaque in the observation group were significantlygreater than those in the control group, but the comparison of hard plaque between the twogroups was not statistically significant. The levels of TC and LDL-C in the observation groupwere significantly higher than those in the control group, while HDL-C level was significantlylower than that in the control group. The positive rate of CP IgG in the observation group wassignificantly higher than that in the control group. Conclusions: Chlamydia pneumoniae hasan important effect on the lipid metabolism of mononuclear macrophages in patients withcarotid atherosclerotic plaque.