Inflammatory response, stress response and urodynamic changes after total pelvic floor reconstruction in patients with pelvic organ prolapse

摘要

Objective: To investigate the changes of inflammatory response, stress response andurodynamic changes after total pelvic floor reconstruction in patients with pelvic organprolapse. Methods: According to random data table method, 80 cases of pelvic organ prolapsewere randomly divided into the control group (n=40) and observation group (n=40), patients inthe control group were given conventional vaginal hysterectomy plus vaginal wall repair sugeryand the observation group received total pelvic floor reconstruction. The levels of the seruminflammatory factor,oxidative stress before and after surgery, and postoperative urodynamicchanges were compared. Results: The levels of serum hs-CRP, IL-1β,TNF-α, NE, E and Insin the two groups before treatment were not statistically significant. Compared with the groupbefore treatment, the levels of hs-CRP, IL-1β, TNF-α, NE, E were significantly increasedin both groups after treatment, and the observation group levels were significantly lower thanthose in the control group after treatment; in terms of urodynamics, the postoperative maximalbladder volume and Qmax were significantly higher in the observation group than in thecontrol group, the postoperative levels of PdetQMax, PdetMax and PVR in the observationgroup were significantly lower than those in the control group. Conclusion: Compared withvaginal hysterectomy plus vaginal wall repair sugery, total pelvic floor reconstruction can lightthe patient's inflammation, stress response and improve the patient's urinary function, and theoverall effect is better which has important clinical value.