T-bet, GATA-3 and Foxm1 expression in chronic sinusitis mucosa and their correlation with inflammatory molecule expression

摘要

Objective: To study the T-bet, GATA-3 and Foxm1 expression in chronic sinusitis mucosa andtheir correlation with inflammatory molecule expression. Methods: Patients with sinusitis anddeflection of nasal septum who received nasal endoscopic surgery in Shengli hospital betweenJune 2015 and February 2017 were selected and enrolled in CRS group and control grouprespectively. The nasal mucosa tissue was collected during operation to determine the mRNAexpression of T-bet, GATA-3 and Foxm1 as well as the protein expression of inflammatorymolecules. Results: T-bet, GATA-3 and Foxm1 mRNA expression as well as IL-1β, IFN-γ,TNF-α, IL-4, IL-5, IL-19, IL-20R1, IL-20R2, MMP2, MMP9, PI3K, Akt, GSK-3β andp38MAPK protein expression in nasal mucosa tissue of CRS group were significantly higherthan those of control group; T-bet, GATA-3 and Foxm1 mRNA expression in nasal mucosatissue of patients with CRS were positively correlated with IL-1β, IFN-γ, TNF-α, IL-4,IL-5, IL-19, IL-20R1, IL-20R2, MMP2, MMP9, PI3K, Akt, GSK-3β and p38MAPK proteinexpression. Conclusions: The high expression of T-bet, GATA-3 and Foxm1 in chronicsinusitis mucosa tissue can activate Th1 and Th2 immune response and cause mucosalinflammatory response.