Correlation between SP-D content in cerebrospinal fluid and severity of viral encephalitis

摘要

Objective: To detect the content of SP-D in cerebrospinal fluid(CSF) of children with viralencephalitis, evaluate the correlation between SP-D and indexes of brain injury, inflammatoryreaction and cellular immune disorder. Methods: 78 cases of viral encephalitis childrendiagnosed in our hospital during December 2016 to May 2018 were selected as Viralencephalitis group, 51 cases of fever without intracranial infection children were selected asControl group. The cerebrospinal fluid samples of two groups were taken and SP-D, braininjury-related indicators, inflammatory indicators and T lymphocyte subsets were detected.Pearson test was used to analyze the relationship between SP-D content in CSF and aboveindicators. Results: Content of SP-D in CSF of Viral encephalitis group was lower thanthat of control group (P0.05). Contents of MBP, CK-BB, NSE and S100B in CSF of Viralencephalitis group were higher than those of Control group; contents of IL-1β, TNF-αand ICAM-1 in CSF of Viral encephalitis group were higher than those of Control group;distribution proportion of CD3+, CD4+ T lymphocytes and CD4+/CD8+ ratio in CSF werelower than those of Control group, and levels of CD8+ were higher than that of Control group(P0.05). Correlation analysis showed that, SP-D content in CSF of viral encephalitis childrenwas directly related to brain injury indexes, inflammatory indexes and T lymphocyte subsetsdistribution levels(P0.05). Conclusion: Content of SP-D in CSF of viral encephalitis childrendecreases abnormally, the specific content is directly related to the degree of brain injury,intracranial inflammation and cellular immune dysfunction. It is important to evaluate theseverity of the disease.