Clinical correlation between blood glucose control-related factors and postoperative fundus hemorrhage after pan-retinal photocoagulation for diabetic retinopathy

摘要

Objective: To discuss the clinical correlation between blood glucose control-related factors and postoperative fundus hemorrhage after pan-retinal photocoagulation (PRP) for diabetic retinopathy (DR). Method: From February 2013 to January 2017, 98 patients at 7 d after PRP for DR were recruited. Depending on postoperative fundus status, the patients were divided into normal fundus group (n=42), fundus hemorrhage group (n=30) and proliferative DR group (n=27). The baseline data and monitoring data of blood glucose and blood lipid were recorded. Dynamic glucose monitor system was used to detect indicators of blood glucose fluctuation, MAGE and MBG. Result: The three groups were compared in terms of systolic pressure, diastolic pressure, course of disease, gender, age and body mass index (BMI), and no significant differences were found. As compared with the normal fundus group, the fundus hemorrhage group and proliferative DR group had a significant increase in FPG, HbA1c, 2hPG, LDL-C and TC, but a decrease in HDL-C. MAGE and MBG for the fundus hemorrhage group were (4.89±1.42) and (7.82±1.42), respectively, which were higher than those of the normal fundus group, but no significantly different from those of the proliferative DR group. Linear correlation analysis was performed in 98 patients, and significant linear correlations existed between MAGE, MBG, FPG, HbA1c and LDL-C with fundus hemorrhage. Conclusion: Blood glucose control-related factors MAGE, MBG, FPG, HbA1c and LDL-C were important influence factors of fundus hemorrhage following PRP for DR. Appropriate countermeasures are needed to reduce the fluctuation of blood glucose level.