Effect of buprenorphine transdermal patch combined with patient-controlled intravenous analgesia on the serum pain-related biochemical indexes in elderly patients with intertrochanteric fracture

摘要

Objective: To study the effect of buprenorphine transdermal patch combined with patientcontrolledintravenous analgesia on the serum pain-related biochemical indexes in elderlypatients with intertrochanteric fracture. Methods: A total of 92 elderly patients withintertrochanteric fracture who received surgical treatment in the hospital between August2014 and January 2017 were collected and divided into control group (n=46) and observationgroup (n=46) according to the random number table method. The control group receivedpatient-controlled intravenous analgesia, and the observation group received buprenorphinetransdermal patch combined with patient-controlled intravenous analgesia. Differences inserum levels of inflammatory factors, oxidative stress indexes and pain mediators of twogroups of patients were measured before and 24h after surgery. Results: Differences inserum levels of inflammatory factors, oxidative stress indexes and pain mediators were notstatistically significant between the two groups before surgery; 24 h after surgery, serum IL-1β, IL-6, IL-8, TNF-α, MDA, SP, PGE2, 5-HT, HA and NPY levels of both groups ofpatients increased significantly while SOD, TAC and CAT levels decreased significantly, andserum IL-1β, IL-6, IL-8, TNF-α, MDA, SP, PGE2, 5-HT, HA and NPY levels of observationgroup were lower than those of control group while SOD, TAC and CAT levels were higherthan those of control group. Conclusion: Buprenorphine transdermal patch combined withpatient-controlled intravenous analgesia can effectively inhibit the expression of pain-relatedindexes and relieve early postoperative pain intensity in elderly patients with intertrochantericfracture.