Effects of preoperative trimetazidine application on myocardial injury indexes and oxidative stress indexes in patients with AMI after PCI

摘要

Objective: To investigate the effects of preoperative trimetazidine application on myocardial injury indexes and oxidative stress indexes in patients with AMI after PCI. Methods: A total of 70 patients with AMI who received emergency PCI in this hospital between January 2015 and January 2018 were divided into the control group (n=35) (received no trimetazidine) and the trimetazidine group (n=35) (received trimetazidine) according to the application of trimetazidine before PCI or not. The differences in the contents of myocardial injury markers, inflammatory factors and oxidative stress indexes were compared between the two groups immediately after admission and after surgery. Results: Immediately after admission, the differences in serum levels of myocardial injury markers, inflammatory factors and oxidative stress indexes were not statistically significant between the two groups of patients. Twenty-four hours after surgery, serum myocardial injury markers CK-MB, cTnⅠ, Myo and h-FABP levels of trimetazidine group were lower than those of control group; inflammatory factors hs-CRP, Neopterin and IL-1β levels were lower than those of control group; oxidative stress index SOD level was higher than that of control group whereas MDA and LHP levels were was lower than those of control group. Conclusion: Trimetazidine treatment before PCI can effectively optimize the postoperative cardiac function and reduce the oxidative stress response in patients with AMI.