Effect of monosialotetrahexosyl ganglioside sodium on inflammatory reaction, stress response and humoral immunity in patients with traumatic brain injury

摘要

Objective: To investigate the effects of monosialotetrahexosyl ganglioside sodium on inflammatory response, stress response and humoral immunity in patients with traumatic brain injury. Methods: A total of 100 patients with traumatic brain injury treated in our hospital from January 2015 to August 2017 were selected as the research object and divided into observation group and control group according to the random number table, each with 50 cases. The control group was given routine treatment while the observation group was given monosialotetrahexosyl ganglioside sodium on the basis of the control group. The changes of inflammatory response, stress response and humoral immunity were compared between the two groups. Results: Before treatment, there was no significant difference in inflammatory factors CRP, TNF-alpha, NPY level, stress response index MAP, HR, NE, Cor level, humoral immune index IgG, IgM and IgA levels between the two groups. After treatment, the levels of CRP, TNF-α and NPY in the two groups were significantly lower than those before treatment, and CRP level in the observation group (9.31±2.04) mg/L, TNF-α level (1.47±0.14) ng/L, NPY level (70.02±5.28) ng/L were significantly lower than the corresponding levels of the control group. After treatment, the levels of MAP, NE and Cor in the two groups were significantly lower than those before treatment, HR was significantly higher than before treatment. After treatment, the MAP level (112.07±14.58) mmHg, NE (404.73±105.79) pmol/L and Cor (201.31±42.34) ng/Lin observation group were significantly lower than those in control group; HR level (76.34±5.11) times/min was significantly higher than that of the control group. After treatment, the levels of IgG, IgM and IgA in both groups were significantly higher than those before treatment, and the IgG level (19.02±2.28) g/L, IgM level (2.64±0.42) g/L, IgA level (4.31±0.48) g/L in the observation group were significantly higher than the corresponding levels in the control group. Conclusions: Sodium monosialotetrahexose ganglioside treatment of patients with traumatic brain injury can significantly improve the body's inflammatory response, control the level of postoperative stress response, and improve the level of humoral immunity in patients. It is worthy of clinical promotion.