Correlation between plasma VEGFA expression level of chronic obstructive pulmonary disease in Li and Han nationalities in Hainan

摘要

Objective: To analyze the relationship between plasma vascular endothelial growth factorand patients with chronic obstructive pulmonary disease in Hainan Li and Han nationality,and the correlation between VEGFA and COPD after different stratification, to explore thesignificance of VEGFA in the diagnosis and treatment of Li people with chronic obstructivepulmonary disease. Methods: 249 patients with COPD were recruited in Hainan (109 casesof Li and 140 cases of Han), and 246 cases in the control group (89 cases of Li; 157 casesof Han ) From July 2014 to March 2015, We measured plasma vascular endothelial growthfactor protein levels ,and determined the expression difference of plasma VEGFA in patientswith chronic obstructive pulmonary disease and healthy controls according to different races,genders, smoking status, etc.,and analyzed the correlation between the expression of VEGFAin patients with chronic obstructive pulmonary disease in Li and Han in Hainan. Conclusion:(1) In the Li population, the expression of VEGFA of COPD patients and healthy controls waslower than that of Han (P0.05); (2) The causes of elevated VEGFA levels in the plasma of theLi population are: high BMI, advanced age, use of wood, hay,recent respiratory infections andAECOPD; (3) The causes of elevated VEGFA levels in plasma in Han population are: COPD,low education level, smoking age, repeated respiratory infection, family history of respiratorydiseases, frequent coughing, recent respiratory infection and acute COPD Aggravation period;(4) In the AECOPD, the expression of VEGFA in plasma was higher than that in stable phaseand control group; the expression of plasma VEGFA in stable phase of COPD was lower thanthat in the control group.