Kidney injury molecule-1 and its diagnostic ability in various clinical conditions

摘要

Objectives: This review evaluates the diagnostic ability of Kidney Injury Molecule 1 (Kim-1) in various clinical conditions. Methods: We screened literature in electronic database from January 2016 to March 2016 by the words “Kidney Injury Molecule-1”or “Kim-1” and “Acute Kidney Injury”. Specific studies were selected for inclusion if they were published in English journals, in which Kim-1 was measured for diagnosis of various forms of Acute Kidney Injury in different articles. Results: There were eight articles which met the selection criteria for inclusion in our study. Compared to non acute kidney injury (AKI) patients, Kim-1 raised significantly in different forms of AKI patients. Conclusions: Kidney Injury Molecule-1 is a new emerging urinary biomarker in the early detection of acute kidney injury and repair of kidney cells as well. Kim-1 can detect acute tubular necrosis, a useful marker for renal proximal tubular injury and it can restore morphological integration of kidney cells followed by ischemic injury. Kim-1 can detect nephrotoxic injury and injury caused by various drugs as well.