DEVELOPMENT AND CHARACTERIZATION OF SRM MICROSPHERES OF REPAGLINIDE

摘要

The aim of current work to develop and evaluate sustained release mucoadhesive (SRM) microspheres of Repaglinide using emulsification solvent evaporation technique. Effects of formulation variables i.e. polymer concentration and phase volume ratio on particle size, % mucoadhesion and drug release were investigated in this study. Scanning electron microscopy of microspheres with maximum drug content (Formulation CH1:8) demonstrated smooth surface spherical particles with mean diameter of 64.78 ± 3.26 μm. The mean Particle size, % drug loading and mucoadhesion were found to vary by changing the formulation variables. Microspheres size was significantly increased as increasing the polymer concentration in the aqueous phase while size of microspheres decrease as increase in volume of continuous phase. Decrease in size of microspheres leads to decrease in mucoadhesion time, % drug loading and faster the drug release. It can be concluded that the present mucoadhesive microspheres can be an ideal system to deliver the Repaglinide in sustained release manner for management of Type II Diabetes Mellitus.