Comparison of the Freestyle Lite? Blood Glucose Monitoring System to the Yellow Springs Instruments Glucose Oxidase Analyzer for Use during Glucose Clamp Studies in Nondiabetic Subjects Undergoing Magnetic Resonance Imaging

摘要

H yperinsulinemic–euglycemic clamp studies are considered the gold standard for quantifying insulin resistance in humans. These procedures involve maintaining glucose at a target level during infusion of a fixed dose of insulin by measuring glucose every 2 to 5 minutes and varying the rate of a dextrose infusion. Thus a rapid and accurate real-time method for glucose determination is needed. A bedside reference-quality automated glucose-oxidase-based analyzer such as the YSI 2300 STAT (YSI; Yellow Springs Instruments Incorporated, Yellow Springs, OH) is usually used for this purpose. However, measurements by these instruments are typically delayed several minutes from the time of blood sampling and may be delayed further during required periodic instrument calibrations.