Nanotechnology Based Approaches For Enhancements of Bioavailability of Sustain Release Formulation

摘要

In recent years drug bioavailability has become a subject of matter not only in drug development, additionally within the early stages of drug discovery. Bioavaibility is the major and important pharmacokinetic property of drug. This property of drug is used to describe the fraction of an administered dose of unchanged drug which can reaches to the systemic circulation. When a drug is administered intravenously, its bioavailability is 100%.and if the drug is administered through other routes like oral, its bioavailability decreases because of the incomplete absorption or first pass metabolism. So there is a need in the enhancement of the bioavaibility of sustained release dosage form.This is a consequence of the finding that the majority of candidate drugs that were unsuccessful in clinical trials did so because of problems with absorption, distribution, metabolism, excretion (ADME) and toxicology. Efforts are being created within the Pharmaceutical industry to improve success rates by taking into account the ADME and toxicology aspects in drug discovery. The efficacy of a drug further depends on the ability of the dosage to deliver the active drug to the site of action and at a rate and amount which is sufficient to show the desired pharmacological response. This property is also known as bioavaibility or biologic avaibility.