Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population

摘要

Background Recent evidences have revealed that resistin is associated with the development of rheumatoid arthritis (RA). The aim of this study was to analyze the association of resistin gene single nucleotide polymorphisms (SNPs) with RA susceptibility. Methods In this study, we finally analyzed three resistin SNPs (rs1862513, rs3745368, and rs3745367) in 278 RA patients and 276 normal controls recruited from Chinese population using TaqMan SNP genotyping assays. Results There were no significant differences for the distribution of allele and genotype frequencies of these three SNPs between RA patients and normal controls (all P .05). The genotype effects of dominant, recessive models were also analyzed, and no significant association was detected (all P .05). Haplotype analysis suggested that the frequency of haplotype GAA was notably lower in RA patients in comparison with normal controls (OR = 0.317, 95% CI: 0.125‐0.807, P = .011). Conclusion In a ward, our results indicated that resistin gene polymorphisms might affect the genetic predisposition of RA in Chinese population.